Neuroblastoom, borstkanker, prostaatkanker, leverkanker, darmkanker en huidkanker; alkylglycerol (ω-3 FAs) kan een beschermend effect hebben.
In 2016 is een publicatie in Scientifica verschenen over:
Biochemische karakteristiek van shark liver oil (alkylglycerol) en een cytotoxische (cel dodende) evaluatie op neuroblastoom cellijnen.
In het artikel wordt uiteengezet dat zogenaamde ω-3 FAs (fatty acids) dit beschermend effect kunnen hebben.
Kern is dat het westerse dieet evenredig hoge hoeveelheden ω-6 vetzuren en lage hoeveelheden van ω-3 vetzuren bevatten, het resulteert in een hoge ω-6/ω-3 ratio die wordt verbonden aan verschillende ziekten.
De publikatie is uitgebracht in een Research uitgave Scientifica met als originele titel:
Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y)
In de introductie vindt u dit overzicht omtrent de ondersteuning die alkylglycerol kan bieden volgens dit artikel:
Shark liver oil contains a group of ether-linked glycerol known as 1-O-alkylglycerols, n-3 PUFA, squalene, and some vitamins. These components have been reported to present multiple biologic activities, including inhibition of tumor growth [6, 7] and enhancement of both macrophage activation [8] and specific immunity in rodents and humans [9]. Because of its dual content of n-3 PUFA and alkylglycerols, shark liver oil is of particular interest in nutrition. The liver oil extracted from these sharks was used in treatment of various diseased conditions like infectious diseases and cancer [10]. Shark liver oil is found to be rich in various vitamins like vitamin A and tocopherol [11]. The oil extracted from deep sea sharks contains a towering level of PUFA, squalene, alkylglycerols, and trivial levels of free fatty acid, sterol, pristane, and wax ester [12]. Certain bioactive compounds, namely, alkylglycerol and their derivatives, have established influence on many physiological mechanisms in the human body. Antiproliferative effect of alkylglycerol against colon cancer cells has already been reported [13]. Squalene and alkyl glycerol and some fatty acids have been reported to have anticarcinogenic effect against mammalian carcinoma. The western diet contains disproportionately high levels of ω-6 and low levels of ω-3 fatty acids, resulting in high ω-6/ω-3 ratios that are linked to multiple pathological conditions. Animal and human studies suggested that decreasing ω-6/ω-3 ratio ameliorates cardiovascular disease and improves body’s other metabolic outcomes [14]. Recently there has been a keen interest in exploring the role of ω-3 FAs in several diseased conditions [15]. Although the efficacy of ω-3 FAs in human cancer remains inconclusive, in vitro and in vivo animal studies suggest that ω-3 FAs may have a protective effect against breast, prostate, liver, colon, and skin cancer in addition to neuroblastoma [16–20]. Neuroblastoma (NB) is one among the most common extra cranial solid cancers in children and the most common one during infancy with a very high severity. When it comes to the cancer treatment, chemotherapy is the most employed method of treatment for cancers in addition to radioactive therapy, but they have numerous side effects and hence the search for an alternative medicine with no or little side effect is a prerequisite.
Klik op de tekst van het artikel voor de link naar het origineel.
De nummer referenties 6, 7, 9, 13, 16 – 20 verwijzen naar de onderstaande originele publicaties . Volg de links bij de publicatie voor nadere informatie:
6)
A. Brohult, J. Brohult, and S. Brohult, “Regression of tumour growth after administration of alkoxyglycerols,” Acta Obstetricia et Gynecologica Scandinavica, vol. 57, no. 1, pp. 79–83, 1978. View at Publisher · View at Google Scholar · View at Scopus
7)
F. Pédrono, B. Martin, C. Leduc et al., “Natural alkylglycerols restrain growth and metastasis of grafted tumors in mice,” Nutrition and Cancer, vol. 48, no. 1, pp. 64–69, 2004. View at Publisher · View at Google Scholar · View at Scopus
9)
B. Z. Ngwenya and D. M. Foster, “Enhancement of antibody production by lysophosphatidylcholine and alkylglycerol,” Proceedings of the Society for Experimental Biology and Medicine, vol. 196, no. 1, pp. 69–75, 1991. View at Publisher · View at Google Scholar · View at Scopus
13)
S. Molina, M. I. Moran-Valero, D. Martin et al., “Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells,” Chemistry and Physics of Lipids, vol. 175-176, pp. 50–56, 2013. View at Publisher · View at Google Scholar · View at Scopus
16)
M. Iigo, T. Nakagawa, C. Ishikawa et al., “Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung,” British Journal of Cancer, vol. 75, no. 5, pp. 650–655, 1997. View at Publisher ·View at Google Scholar · View at Scopus
17)
T. Yuri, N. Danbara, M. Tsujita-Kyutoku et al., “Dietary docosahexaenoic acid suppresses N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats more effectively than eicosapentaenoic acid,” Nutrition and Cancer, vol. 45, no. 2, pp. 211–217, 2003. View at Publisher · View at Google Scholar · View at Scopus
18)
U. P. Kelavkar, J. Hutzley, R. Dhir, P. Kim, K. G. D. Allen, and K. McHugh, “Prostate tumor growth and recurrence can be modulated by the ω-6:ω-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy,” Neoplasia, vol. 8, no. 2, pp. 112–124, 2006. View at Publisher · View at Google Scholar · View at Scopus
19)
K. Lim, C. Han, Y. Dai, M. Shen, and T. Wu, “Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking β-catenin and cyclooxygenase-2,” Molecular Cancer Therapeutics, vol. 8, no. 11, pp. 3046–3055, 2009. View at Publisher · View at Google Scholar · View at Scopus
20)
H. Gleissman, L. Segerström, M. Hamberg et al., “Omega-3 fatty acid supplementation delays the progression of neuroblastoma in vivo,” International Journal of Cancer, vol. 128, no. 7, pp. 1703–1711, 2011. View at Publisher · View at Google Scholar · View at Scopus
